Version 5.4
Homo sapiens Protein: CMBL
Summary
InnateDB Protein IDBP-12378.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CMBL
Protein Name carboxymethylenebutenolidase homolog (Pseudomonas)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000296658
InnateDB Gene IDBG-12376 (CMBL)
Protein Structure
UniProt Annotation
Function Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin. {ECO:0000269PubMed:20177059}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000269PubMed:20177059}.
Disease Associations
Tissue Specificity Widely expressed, with highest levels in liver, followed by kidney, small intestine and colon. Present in liver and intestine (at protein level). {ECO:0000269PubMed:20177059}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002925 Dienelactone hydrolase
IPR003140 Phospholipase/carboxylesterase/thioesterase
IPR029058 Alpha/Beta hydrolase fold
PFAM PF01738
PF02230
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96DG6
PhosphoSite PhosphoSite-Q96DG6
TrEMBL
UniProt Splice Variant
Entrez Gene 134147
UniGene Hs.736191
RefSeq NP_620164
HUGO HGNC:25090
OMIM 613379
CCDS CCDS3878
HPRD 14055
IMGT
EMBL AJ278125 AK074197 BC001573 CH471102
GenPept AAH01573 BAB85014 CAC81950 EAX08070 EAX08071

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca