InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HCN2

Summary

InnateDB Protein

IDBP-12526.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HCN2

Protein Name

hyperpolarization activated cyclic nucleotide-gated potassium channel 2

Synonyms

BCNG-2; BCNG2; HAC-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000251287

InnateDB Gene

IDBG-12524 (HCN2)

Protein Structure

UniProt Annotation

Function

Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:10228147, ECO:0000269PubMed:10524219}; Multi-pass membrane protein {ECO:0000269PubMed:10228147, ECO:0000269PubMed:10524219}.

Disease Associations

Tissue Specificity

Highly expressed throughout the brain. Detected at low levels in heart. {ECO:0000269PubMed:10228147, ECO:0000269PubMed:9630217}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005222	intracellular cAMP activated cation channel activity
GO:0005248	voltage-gated sodium channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005515	protein binding
GO:0030552	cAMP binding
GO:0042802	identical protein binding

Biological Process

GO:0006811	ion transport
GO:0007267	cell-cell signaling
GO:0007268	synaptic transmission
GO:0034765	regulation of ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0055085	transmembrane transport
GO:0071320	cellular response to cAMP
GO:0071321	cellular response to cGMP
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000595 Cyclic nucleotide-binding domain
IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
IPR005821 Ion transport domain
IPR013621 Ion transport N-terminal
IPR018490 Cyclic nucleotide-binding-like

PFAM

PF00027
PF00520
PF08412

PRINTS

PR01463

PIRSF

SMART

SM00100

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt