Version 5.4
Homo sapiens Protein: ANLN
Summary
InnateDB Protein IDBP-12577.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANLN
Protein Name anillin, actin binding protein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000265748
InnateDB Gene IDBG-12575 (ANLN)
Protein Structure
UniProt Annotation
Function Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. {ECO:0000269PubMed:10931866, ECO:0000269PubMed:12479805, ECO:0000269PubMed:15496454, ECO:0000269PubMed:16040610, ECO:0000269PubMed:16357138}.
Subcellular Localization Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Mainly found in the nucleus during interphase. Colocalizes with cortical F-actin upon nuclear envelope breakdown in mitosis and subsequently concentrates in the area of the prospective contractile ring in anaphase. This pattern persists until telophase, when the protein becomes concentrated in the midbody.
Disease Associations
Tissue Specificity Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors. {ECO:0000269PubMed:16203764}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
Biological Process
GO:0000281 mitotic cytokinesis
GO:0000921 septin ring assembly
GO:0002244 hematopoietic progenitor cell differentiation
GO:0007067 mitotic nuclear division
GO:0007096 regulation of exit from mitosis
Cellular Component
GO:0005634 nucleus
GO:0005826 actomyosin contractile ring
GO:0015629 actin cytoskeleton
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR001849 Pleckstrin homology domain
PFAM PF00169
PRINTS
PIRSF
SMART SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NQW6
PhosphoSite PhosphoSite-Q9NQW6
TrEMBL C9JJT6
UniProt Splice Variant
Entrez Gene 54443
UniGene Hs.62180
RefSeq NP_061155
HUGO HGNC:14082
OMIM
CCDS CCDS5447
HPRD 09799
IMGT
EMBL AC006960 AF273437 AK001468 AK001472 AK023208 BC034692 BC070066 CH471073 CR936650
GenPept AAF75796 AAH34692 AAH70066 BAA91710 BAA91711 BAB14463 CAI56788 EAW94071 EAW94072

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca