InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FGF22

Summary

InnateDB Protein

IDBP-12622.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGF22

Protein Name

fibroblast growth factor 22

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000215530

InnateDB Gene

IDBG-12620 (FGF22)

Protein Structure

UniProt Annotation

Function

Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development. {ECO:0000269PubMed:16597617}.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005104	fibroblast growth factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0030154	cell differentiation
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling