Version 5.4
Homo sapiens Protein: DGCR14
Summary
InnateDB Protein IDBP-1266.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DGCR14
Protein Name DiGeorge syndrome critical region gene 14
Synonyms DGCR13; DGS-G; DGS-H; DGS-I; DGSH; DGSI; ES2; Es2el; SPOGA2; STK22B; TSK2;
Species Homo sapiens
Ensembl Protein ENSP00000252137
InnateDB Gene IDBG-1264 (DGCR14)
Protein Structure
UniProt Annotation
Function May be involved in pre-mRNA splicing.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in heart, brain and skeletal muscle. Detected at low levels in placenta. {ECO:0000269PubMed:8776594}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0007399 nervous system development
Cellular Component
GO:0005634 nucleus
GO:0071013 catalytic step 2 spliceosome
Protein Structure and Domains
PDB ID
InterPro IPR019148 Nuclear protein DGCR14
PFAM PF09751
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96DF8
PhosphoSite PhosphoSite-Q96DF8
TrEMBL
UniProt Splice Variant
Entrez Gene 8220
UniGene Hs.694070
RefSeq NP_073210
HUGO HGNC:16817
OMIM 610710
CCDS CCDS13756
HPRD 18586
IMGT
EMBL BC003015 BC006542 CR456344 L78010
GenPept AAH03015 AAH06542 AAL40039 CAG30230

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca