Homo sapiens Protein: PIM3 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-12686.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | PIM3 | ||||||||||||||||||
Protein Name | pim-3 oncogene | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000353824 | ||||||||||||||||||
InnateDB Gene | IDBG-12684 (PIM3) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth. {ECO:0000269PubMed:15540201, ECO:0000269PubMed:16818649, ECO:0000269PubMed:17270021, ECO:0000269PubMed:17876606, ECO:0000269PubMed:18593906}. | ||||||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000269PubMed:17876606}. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Detected in various tissues, including the heart, brain, lung, kidney, spleen, placenta, skeletal muscle, and peripheral blood leukocytes. Not found or barely expressed in the normal adult endoderm-derived organs such as colon, thymus, liver, or small intestine. However, expression is augmented in premalignant and malignant lesions of these organs. {ECO:0000269PubMed:15540201, ECO:0000269PubMed:16818649, ECO:0000269PubMed:17270021}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR000719
Protein kinase domain IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain IPR010440 Lipopolysaccharide kinase IPR011009 Protein kinase-like domain IPR020635 Tyrosine-protein kinase, catalytic domain |
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PFAM |
PF00069
PF07714 PF06293 |
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PRINTS |
PR00109
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PIRSF | |||||||||||||||||||
SMART |
SM00220
SM00219 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q86V86 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q86V86 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 415116 | ||||||||||||||||||
UniGene | Hs.644829 | ||||||||||||||||||
RefSeq | NP_001001852 | ||||||||||||||||||
HUGO | HGNC:19310 | ||||||||||||||||||
OMIM | 610580 | ||||||||||||||||||
CCDS | CCDS33678 | ||||||||||||||||||
HPRD | 15137 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AB114795 AK292005 BC052239 BC141855 BX539320 CR536608 | ||||||||||||||||||
GenPept | AAI41856 BAD42438 BAF84694 CAO03523 CAO03581 | ||||||||||||||||||