InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MC5R

Summary

InnateDB Protein

IDBP-1269.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MC5R

Protein Name

melanocortin 5 receptor

Synonyms

MC2;

Species

Homo sapiens

Ensembl Protein

ENSP00000318077

InnateDB Gene

IDBG-1267 (MC5R)

Protein Structure

UniProt Annotation

Function

Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in the brain but not in the melanoma cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004977	melanocortin receptor activity
GO:0005515	protein binding
GO:0042562	hormone binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0030819	positive regulation of cAMP biosynthetic process

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000621 Melanocortin 5 receptor
IPR001671 Melanocortin/ACTH receptor
IPR001908 Melanocortin receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR01063
PR00534
PR00535

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P33032