InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sry

Summary

InnateDB Protein

IDBP-127707.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sry

Protein Name

sex determining region of Chr Y

Synonyms

Tdf; Tdy;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000088717

InnateDB Gene

IDBG-127705 (Sry)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Involved in different aspects of gene regulation including promoter activation or repression. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Promotes DNA bending. Also involved in pre-mRNA splicing (By similarity). Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. {ECO:0000250, ECO:0000269PubMed:15170344}.

Subcellular Localization

Nucleus speckle {ECO:0000255PROSITE- ProRule:PRU00267}. Cytoplasm {ECO:0000269PubMed:11535586, ECO:0000269PubMed:15469996, ECO:0000269PubMed:16488877}. Note=Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH). Colocalizes with SOX6 in speckles (By similarity). Colocalizes with CAML in the nucleus (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the substantia nigra of the brain (at protein level). Expressed in diencephalon, cortex, the substantia nigra of the midbrain and the medial mammillary bodies of the hypothalamus of male, but not female. {ECO:0000269PubMed:11085593, ECO:0000269PubMed:15469996, ECO:0000269PubMed:16488877}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0008301	DNA binding, bending
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007530	sex determination
GO:0008584	male gonad development
GO:0010629	negative regulation of gene expression
GO:0030154	cell differentiation
GO:0030238	male sex determination