InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hepacam2

Summary

InnateDB Protein

IDBP-127823.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hepacam2

Protein Name

HEPACAM family member 2

Synonyms

AI987662;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000058882

InnateDB Gene

IDBG-127821 (Hepacam2)

Protein Structure

UniProt Annotation

Function

Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Midbody {ECO:0000250}. Note=In interphase, localizes to the Golgi apparatus. Localizes to centrosomes and spindles during prophase, prometaphase, and metaphase of mitosis, and to midbodies at telophase. Translocation to mitotic centrosomes is the result of poly-ADP-ribosylation (PARsylation) (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0007067	mitotic nuclear division
GO:0051297	centrosome organization

Cellular Component

GO:0000139	Golgi membrane
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005819	spindle
GO:0016021	integral component of membrane
GO:0030496	midbody

Protein Structure and Domains

PDB ID

MGI:2141520

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF07679
PF07686
PF00047

PRINTS

PIRSF

SMART

SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q4VAH7