Version 5.4
Mus musculus Protein: Tfpi2
Summary
InnateDB Protein IDBP-127876.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tfpi2
Protein Name tissue factor pathway inhibitor 2
Synonyms AV000670; PP5/TFPI-2;
Species Mus musculus
Ensembl Protein ENSMUSP00000031674
InnateDB Gene IDBG-127874 (Tfpi2)
Protein Structure
UniProt Annotation
Function May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin (By similarity). {ECO:0000250}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Highly expressed in placenta. Also expressed in liver and kidney.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0030414 peptidase inhibitor activity
Biological Process
GO:0007596 blood coagulation
GO:0010466 negative regulation of peptidase activity
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:108543
InterPro IPR002223 Proteinase inhibitor I2, Kunitz metazoa
IPR008296 Proteinase inhibitor I2, tissue factor pathway inhibitor
PFAM PF00014
PRINTS PR00759
PIRSF PIRSF001620
SMART SM00131
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O35536
PhosphoSite PhosphoSite-
TrEMBL Q3V1S9
UniProt Splice Variant
Entrez Gene 21789
UniGene Mm.25612
RefSeq NP_033390
MGI ID
MGI Symbol Tfpi2
OMIM
CCDS CCDS19892
HPRD
IMGT
EMBL AF180353 AK132268 BC021639 CH466533 D50586
GenPept AAF40412 AAH21639 BAA22585 BAE21070 EDL13989

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca