InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gngt1

Summary

InnateDB Protein

IDBP-127879.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gngt1

Protein Name

guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1

Synonyms

G(y)1; Gng1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031673

InnateDB Gene

IDBG-127877 (Gngt1)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.

Subcellular Localization

Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.

Disease Associations

Tissue Specificity

Retinal rod outer segment.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity

Biological Process

GO:0006184	GTP catabolic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007602	phototransduction
GO:0008104	protein localization
GO:0010659	cardiac muscle cell apoptotic process
GO:0042462	eye photoreceptor cell development
GO:0071456	cellular response to hypoxia

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0001917	photoreceptor inner segment
GO:0005834	heterotrimeric G-protein complex

Protein Structure and Domains

PDB ID

MGI:109165

InterPro

IPR001770 G-protein, gamma subunit
IPR015898 G-protein gamma-like domain

PFAM

PF00631

PRINTS

PR00321

PIRSF

SMART

SM00224

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61012

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

14699

UniGene

RefSeq

NP_034444

MGI ID

MGI Symbol

Gngt1

OMIM

CCDS

CCDS39418

HPRD

IMGT

EMBL

AK020863 AK020903 BC025929 U38495

GenPept

AAB01726 AAH25929 BAB32232 BAB32247