InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kif5b

Summary

InnateDB Protein

IDBP-127946.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kif5b

Protein Name

kinesin family member 5B

Synonyms

AL022807; Khc; Khcs; Kns1; Ukhc;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025083

InnateDB Gene

IDBG-127944 (Kif5b)

Protein Structure

UniProt Annotation

Function

Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. May be involved in the mechanisms of growth arrest induced by exposure to DNA-damaging drugs or by cellular senescence. {ECO:0000269PubMed:9657148}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Note=Uniformly distributed between soma and neurites in hippocampal neurons. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	49 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003777	microtubule motor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding

Biological Process

GO:0006839	mitochondrial transport
GO:0007017	microtubule-based process
GO:0007018	microtubule-based movement
GO:0007028	cytoplasm organization
GO:0008152	metabolic process
GO:0035617	stress granule disassembly
GO:0042391	regulation of membrane potential
GO:0043268	positive regulation of potassium ion transport
GO:0047496	vesicle transport along microtubule
GO:0072383	plus-end-directed vesicle transport along microtubule
GO:0090004	positive regulation of establishment of protein localization to plasma membrane

Cellular Component

GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0005829	cytosol
GO:0005871	kinesin complex
GO:0005874	microtubule
GO:0016020	membrane
GO:0030139	endocytic vesicle
GO:0031982	vesicle
GO:0035253	ciliary rootlet
GO:0043005	neuron projection
GO:0043227	membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm