InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rab18

Summary

InnateDB Protein

IDBP-128022.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rab18

Protein Name

RAB18, member RAS oncogene family

Synonyms

AA959686;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000095285

InnateDB Gene

IDBG-128020 (Rab18)

Protein Structure

UniProt Annotation

Function

Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration (By similarity). {ECO:0000250}.

Subcellular Localization

Apical cell membrane {ECO:0000305}; Lipid- anchor {ECO:0000305}. Basal cell membrane {ECO:0000305}; Lipid- anchor {ECO:0000305}. Note=Highly enriched on apical endocytic structures in polarized epithelial cells of kidney proximal tubules. Detected on both the apical and basolateral domains in epithelial cells of the intestine.

Disease Associations

Tissue Specificity

Expression is high in the brain, moderate in the pituitary, and low in the liver. Detected in all tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0019003	GDP binding

Biological Process

GO:0001654	eye development
GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007420	brain development
GO:0015031	protein transport
GO:0034389	lipid particle organization

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0009925	basal plasma membrane
GO:0016020	membrane
GO:0016324	apical plasma membrane

Protein Structure and Domains

PDB ID

MGI:102790

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR024156 Small GTPase superfamily, ARF type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF00071
PF00025
PF04670
PF08477

PRINTS

PR00315
PR00449
PR00627
PR00328

PIRSF

SMART

SM00176
SM00174
SM00175
SM00173
SM00177

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt