Version 5.4
Mus musculus Protein: Pfn4
Summary
InnateDB Protein IDBP-128033.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pfn4
Protein Name profilin family, member 4
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000020967
InnateDB Gene IDBG-128029 (Pfn4)
Protein Structure
UniProt Annotation
Function Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid (PA). Does not bind to actin, contrary to other family members (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}.
Disease Associations
Tissue Specificity Detected in testis (at protein level). {ECO:0000269PubMed:15591451}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0008289 lipid binding
Biological Process
GO:0008150 biological_process
GO:0030036 actin cytoskeleton organization
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
Protein Structure and Domains
PDB ID MGI:1920121
InterPro IPR005455 Profilin
PFAM PF00235
PRINTS PR00392
PR01640
PIRSF
SMART SM00392
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D6I3
PhosphoSite PhosphoSite-Q9D6I3
TrEMBL Q6JEK6
UniProt Splice Variant
Entrez Gene 382562
UniGene Mm.251575
RefSeq NP_082652
MGI ID
MGI Symbol Pfn4
OMIM
CCDS CCDS25790
HPRD
IMGT
EMBL AK013595 AY495949 BC116888 BC116890 CH466623
GenPept AAI16889 AAI16891 AAS75143 BAB28919 EDL01357

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca