InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mkx

Summary

InnateDB Protein

IDBP-128043.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mkx

Protein Name

mohawk homeobox

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000078718

InnateDB Gene

IDBG-128041 (Mkx)

Protein Structure

UniProt Annotation

Function

May act as a morphogenetic regulator of cell adhesion. Participates in the early events that lead to differentiation. {ECO:0000269PubMed:16408284}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001085	RNA polymerase II transcription factor binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002932	tendon sheath development
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007517	muscle organ development
GO:0010468	regulation of gene expression
GO:0010628	positive regulation of gene expression
GO:0030199	collagen fibril organization
GO:0032967	positive regulation of collagen biosynthetic process
GO:0035990	tendon cell differentiation
GO:0035992	tendon formation
GO:0045662	negative regulation of myoblast differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter