InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fzd8

Summary

InnateDB Protein

IDBP-128190.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fzd8

Protein Name

frizzled homolog 8 (Drosophila)

Synonyms

Fz8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000039660

InnateDB Gene

IDBG-128188 (Fzd8)

Protein Structure

UniProt Annotation

Function

Receptor for Wnt proteins. Component of the Wnt-Fzd- LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome- sized signalsomes (By similarity). The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G- proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1. {ECO:0000250, ECO:0000269PubMed:10097073, ECO:0000269PubMed:10395542, ECO:0000269PubMed:15454084, ECO:0000269PubMed:16543246}.

Subcellular Localization

Membrane; Multi-pass membrane protein. Golgi apparatus. Cell membrane; Multi-pass membrane protein. Note=Colocalizes with GOPC at the Golgi apparatus.

Disease Associations

Tissue Specificity

Expressed in chondrocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0017147	Wnt-protein binding
GO:0030165	PDZ domain binding
GO:0031625	ubiquitin protein ligase binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001934	positive regulation of protein phosphorylation
GO:0001944	vasculature development
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007409	axonogenesis
GO:0007420	brain development
GO:0008406	gonad development
GO:0033077	T cell differentiation in thymus
GO:0043507	positive regulation of JUN kinase activity
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060070	canonical Wnt signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042995	cell projection