InnateDB Protein
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IDBP-12820.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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EFCAB4B
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Protein Name
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EF-hand calcium binding domain 4B
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000252322
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InnateDB Gene
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IDBG-12818 (EFCAB4B)
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Protein Structure
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Function |
Ca(2+)-binding protein that plays a key role in store- operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. {ECO:0000269PubMed:20418871}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:20418871}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002048
EF-hand domain
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PFAM |
PF00036
PF13202
PF13405
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PRINTS |
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PIRSF |
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SMART |
SM00054
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BSW2
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PhosphoSite |
PhosphoSite-Q9BSW2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
84766
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UniGene |
Hs.737074
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RefSeq |
NP_116069
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HUGO |
HGNC:28657
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OMIM |
614178
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CCDS |
CCDS8522
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HPRD |
10079
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IMGT |
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EMBL |
AC005831
AC006207
AK304017
BC004524
BC150643
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GenPept |
AAH04524
AAI50644
BAG64932
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