InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cpt1a

Summary

InnateDB Protein

IDBP-128205.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cpt1a

Protein Name

carnitine palmitoyltransferase 1a, liver

Synonyms

C730027G07; Cpt1; CPTI;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025835

InnateDB Gene

IDBG-128203 (Cpt1a)

Protein Structure

UniProt Annotation

Function

Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Plays an important role in triglyceride metabolism. {ECO:0000269PubMed:16169268, ECO:0000269PubMed:17030509}.

Subcellular Localization

Mitochondrion outer membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004095	carnitine O-palmitoyltransferase activity
GO:0005515	protein binding
GO:0016746	transferase activity, transferring acyl groups
GO:0042802	identical protein binding

Biological Process

GO:0001676	long-chain fatty acid metabolic process
GO:0006006	glucose metabolic process
GO:0006635	fatty acid beta-oxidation
GO:0006641	triglyceride metabolic process
GO:0006810	transport
GO:0009437	carnitine metabolic process
GO:0014070	response to organic cyclic compound
GO:0030855	epithelial cell differentiation
GO:0032000	positive regulation of fatty acid beta-oxidation
GO:0042493	response to drug
GO:0042755	eating behavior
GO:0046320	regulation of fatty acid oxidation
GO:0050796	regulation of insulin secretion
GO:0051260	protein homooligomerization
GO:0071398	cellular response to fatty acid

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005743	mitochondrial inner membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031307	integral component of mitochondrial outer membrane
GO:0043231	intracellular membrane-bounded organelle