Version 5.4
Mus musculus Protein: Ppp6r3
Summary
InnateDB Protein IDBP-128278.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppp6r3
Protein Name protein phosphatase 6, regulatory subunit 3
Synonyms 4930528G08Rik; 9130026N02Rik; D19Bwg1430e; D19Ertd703e; mKIAA1558; Pp6r3; Ppcs3; Pptcs3; Sapl; Saps3;
Species Mus musculus
Ensembl Protein ENSMUSP00000025846
InnateDB Gene IDBG-128276 (Ppp6r3)
Protein Structure
UniProt Annotation
Function Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Strongest expression observed in lung, spleen, bladder and liver and weaker levels present in brain, heart, kidney, skeletal muscle and pancreas. {ECO:0000269PubMed:16769727}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0019903 protein phosphatase binding
Biological Process
GO:0043666 regulation of phosphoprotein phosphatase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1921807
InterPro IPR007587 SIT4 phosphatase-associated protein family
IPR016024 Armadillo-type fold
PFAM PF04499
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q922D4
PhosphoSite PhosphoSite-Q922D4
TrEMBL
UniProt Splice Variant
Entrez Gene 52036
UniGene Mm.409858
RefSeq NP_083732
MGI ID
MGI Symbol Ppp6r3
OMIM
CCDS CCDS29397
HPRD
IMGT
EMBL AK018652 AK035236 AK088526 AK129392 BC008529
GenPept AAH08529 BAB31326 BAC28993 BAC40403 BAC98202

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca