Mus musculus Protein: Thoc1 | |||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||
InnateDB Protein | IDBP-128302.6 | ||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||
Gene Symbol | Thoc1 | ||||||||||||||||||||||||||||
Protein Name | THO complex 1 | ||||||||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000025137 | ||||||||||||||||||||||||||||
InnateDB Gene | IDBG-128300 (Thoc1) | ||||||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||||||||
Function | Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co- transcriptional R-loop formation (By similarity). {ECO:0000250}.Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1 (By similarity). Essential for early embryonic development. Required for normal gene expression during postnatal testis development. {ECO:0000250, ECO:0000269PubMed:16705185, ECO:0000269PubMed:19307311}. | ||||||||||||||||||||||||||||
Subcellular Localization | Nucleus speckle {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000269PubMed:16705185}. Nucleus matrix {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Can shuttle between the nucleus and cytoplasm. Nuclear localization is required for induction of apoptotic cell death. Translocates to the cytoplasm during the early phase of apoptosis execution (By similarity). {ECO:0000250}. | ||||||||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||||||||
Tissue Specificity | |||||||||||||||||||||||||||||
Comments | |||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||||||||
PDB ID | MGI:1919668 | ||||||||||||||||||||||||||||
InterPro |
IPR000488
Death domain IPR002919 Trypsin Inhibitor-like, cysteine rich domain IPR011029 Death-like domain IPR021861 THO complex, subunit THOC1 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like |
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PFAM |
PF00531
PF01826 PF11957 |
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PRINTS | |||||||||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||||||||
SMART |
SM00005
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TIGRFAMs | |||||||||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||||||||
Modification | |||||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||||
SwissProt | Q8R3N6 | ||||||||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q8R3N6 | ||||||||||||||||||||||||||||
TrEMBL | Q3UTN0 | ||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||
Entrez Gene | 225160 | ||||||||||||||||||||||||||||
UniGene | Mm.219648 | ||||||||||||||||||||||||||||
RefSeq | NP_705780 | ||||||||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||||||||
MGI Symbol | Thoc1 | ||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||
CCDS | CCDS37733 | ||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||
EMBL | AK031785 AK032200 AK042867 AK139307 BC024951 | ||||||||||||||||||||||||||||
GenPept | AAH24951 BAC27548 BAC27754 BAC31387 BAE23950 | ||||||||||||||||||||||||||||