Version 5.4
Mus musculus Protein: C1galt1
Summary
InnateDB Protein IDBP-128321.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C1galt1
Protein Name core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
Synonyms 2210410E06Rik; AV284120; T-synthase;
Species Mus musculus
Ensembl Protein ENSMUSP00000047931
InnateDB Gene IDBG-128319 (C1galt1)
Protein Structure
UniProt Annotation
Function Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development. {ECO:0000269PubMed:14745002, ECO:0000269PubMed:17062753}.
Subcellular Localization Membrane; Single-pass type II membrane protein.
Disease Associations
Tissue Specificity Primarily expressed in endothelial, hematopoietic and epithelial cells during development. {ECO:0000269PubMed:14745002}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008378 galactosyltransferase activity
GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity
GO:0016757 transferase activity, transferring glycosyl groups
GO:0046872 metal ion binding
Biological Process
GO:0001525 angiogenesis
GO:0001822 kidney development
GO:0006486 protein glycosylation
GO:0016267 O-glycan processing, core 1
GO:0030154 cell differentiation
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2151071
InterPro IPR002659 Glycosyl transferase, family 31
IPR003378 Fringe-like
PFAM PF01762
PF02434
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JJ06
PhosphoSite PhosphoSite-Q9JJ06
TrEMBL
UniProt Splice Variant
Entrez Gene 94192
UniGene Mm.102752
RefSeq NP_443719
MGI ID
MGI Symbol C1galt1
OMIM
CCDS CCDS19908
HPRD
IMGT
EMBL AF157962 BC025899 BC064767
GenPept AAF81982 AAH25899 AAH64767

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca