Version 5.4
| Mus musculus Protein: Tgs1 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-128355.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Tgs1 | ||||||||
| Protein Name | trimethylguanosine synthase homolog (S. cerevisiae) | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000054112 | ||||||||
| InnateDB Gene | IDBG-128351 (Tgs1) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Cytoplasm {ECO:0000250}. Nucleus, Cajal body {ECO:0000269PubMed:11517327}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Ubiquitously expressed. {ECO:0000269PubMed:11517327}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:2151797 | ||||||||
| InterPro |
IPR000241
Putative RNA methylase domain IPR003402 tRNA transferase Trm5/Tyw2 IPR019012 RNA cap guanine-N2 methyltransferase IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like |
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| PFAM |
PF01170
PF02475 PF09445 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART | |||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q923W1 | ||||||||
| PhosphoSite | PhosphoSite-Q923W1 | ||||||||
| TrEMBL | Q8CCI3 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 116940 | ||||||||
| UniGene | Mm.482607 | ||||||||
| RefSeq | NP_473430 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Tgs1 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS17938 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AF389908 AK033089 AL732617 BC026368 BC058183 BC075728 | ||||||||
| GenPept | AAH26368 AAH58183 AAH75728 AAK84355 BAC28147 CAM17201 | ||||||||