InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gdnf

Summary

InnateDB Protein

IDBP-128380.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gdnf

Protein Name

glial cell line derived neurotrophic factor

Synonyms

AI385739;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022744

InnateDB Gene

IDBG-128378 (Gdnf)

Protein Structure

UniProt Annotation

Function

Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed in both the central nervous system (CNS) and in non-CNS tissues. Expressed in a highly dynamic pattern in the anterior neuroectoderm during the early stages of neurogenesis between E7.5 and E10.5. Beginning at E10.5, expression begins in mesenchymal tissues of several organs including the digestive tract, kidney, testis, frontonasal mass, tooth primordium, tongue, mandible, whisker follicles, ear, eye, limb bud and in distinct regions of the brain. Also expressed in the heart, ileum, liver and muscle. {ECO:0000269PubMed:12168040, ECO:0000269PubMed:8808409}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005160	transforming growth factor beta receptor binding
GO:0008083	growth factor activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0001656	metanephros development
GO:0001657	ureteric bud development
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001755	neural crest cell migration
GO:0001759	organ induction
GO:0001941	postsynaptic membrane organization
GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007399	nervous system development
GO:0007422	peripheral nervous system development
GO:0021784	postganglionic parasympathetic nervous system development
GO:0030432	peristalsis
GO:0031175	neuron projection development
GO:0032770	positive regulation of monooxygenase activity
GO:0043524	negative regulation of neuron apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048255	mRNA stabilization
GO:0048484	enteric nervous system development
GO:0048485	sympathetic nervous system development
GO:0051584	regulation of dopamine uptake involved in synaptic transmission
GO:0060676	ureteric bud formation
GO:0060688	regulation of morphogenesis of a branching structure
GO:0072107	positive regulation of ureteric bud formation
GO:0072108	positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand