InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Matn3

Summary

InnateDB Protein

IDBP-128509.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Matn3

Protein Name

matrilin 3

Synonyms

AV009181;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020899

InnateDB Gene

IDBG-128507 (Matn3)

Protein Structure

UniProt Annotation

Function

Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks. {ECO:0000269PubMed:10660556}.

Subcellular Localization

Secreted {ECO:0000269PubMed:10660556}.

Disease Associations

Tissue Specificity

Strongly expressed in growing skeletal tissue such as epiphyseal growth plate or in bone undergoing growth and remodeling. In the bone, actively synthesized in osteoblasts and osteocytes. Expressed in cartilage of sternum, femur, vertebrae, trachea, articular and epiphyseal cartilage, cartilage of developing bones and bones.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

Cellular Component

GO:0005578

proteinaceous extracellular matrix

Protein Structure and Domains

PDB ID

MGI:1328350

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001881 EGF-like calcium-binding domain
IPR002035 von Willebrand factor, type A
IPR019466 Matrilin, coiled-coil trimerisation domain

PFAM

PF00008
PF07645
PF00092
PF10393

PRINTS

PIRSF

SMART

SM00181
SM00179
SM00327

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O35701