Version 5.4
Mus musculus Protein: Ndufs8
Summary
InnateDB Protein IDBP-128515.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ndufs8
Protein Name NADH dehydrogenase (ubiquinone) Fe-S protein 8
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000074600
InnateDB Gene IDBG-128513 (Ndufs8)
Protein Structure
UniProt Annotation
Function Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003954 NADH dehydrogenase activity
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0016651 oxidoreductase activity, acting on NAD(P)H
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006979 response to oxidative stress
GO:0032981 mitochondrial respiratory chain complex I assembly
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005747 mitochondrial respiratory chain complex I
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:2385079
InterPro IPR001450 4Fe-4S binding domain
IPR010226 NADH-quinone oxidoreductase, chain I
PFAM PF00037
PF12797
PF12798
PF12800
PF12801
PF12837
PF12838
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K3J1
PhosphoSite PhosphoSite-Q8K3J1
TrEMBL Q5M9P5
UniProt Splice Variant
Entrez Gene 225887
UniGene
RefSeq NP_659119
MGI ID
MGI Symbol Ndufs8
OMIM
CCDS CCDS29402
HPRD
IMGT
EMBL AK149674 AK153182 AK153900 AK164901 AK167907 AY096002 BC086766 CH466612
GenPept AAH86766 AAM34451 BAE29018 BAE31784 BAE32243 BAE37960 BAE39914 EDL32969 EDL32970

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca