InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aldh3b1

Summary

InnateDB Protein

IDBP-128530.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aldh3b1

Protein Name

aldehyde dehydrogenase 3 family, member B1

Synonyms

1700001N19Rik; ALDH4; ALDH7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000056276

InnateDB Gene

IDBG-128528 (Aldh3b1)

Protein Structure

UniProt Annotation

Function

Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. May use both NADP(+) and NAD(+) as cofactors. May have a protective role against the cytotoxicity induced by lipid peroxidation. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Primarily in the plasma membrane as well as in some punctate structures in the cytoplasm. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in kidney and liver. In brain is expressed at moderate levels in cortex, striatum and hippocampus, and at lower levels in brainstem and cerebellum. {ECO:0000269PubMed:17382292}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity
GO:0016491	oxidoreductase activity

Biological Process

GO:0006068	ethanol catabolic process
GO:0006081	cellular aldehyde metabolic process
GO:0008152	metabolic process
GO:0034599	cellular response to oxidative stress
GO:0046185	aldehyde catabolic process
GO:0055114	oxidation-reduction process