InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cyp7a1

Summary

InnateDB Protein

IDBP-128574.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyp7a1

Protein Name

cytochrome P450, family 7, subfamily a, polypeptide 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029905

InnateDB Gene

IDBG-128572 (Cyp7a1)

Protein Structure

UniProt Annotation

Function

Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis. {ECO:0000269PubMed:14522988}.

Subcellular Localization

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0008123	cholesterol 7-alpha-monooxygenase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding

Biological Process

GO:0006699	bile acid biosynthetic process
GO:0006707	cholesterol catabolic process
GO:0042632	cholesterol homeostasis
GO:0055114	oxidation-reduction process
GO:0070857	regulation of bile acid biosynthetic process
GO:0070859	positive regulation of bile acid biosynthetic process
GO:0071333	cellular response to glucose stimulus
GO:0071397	cellular response to cholesterol