InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nipbl

Summary

InnateDB Protein

IDBP-128594.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nipbl

Protein Name

Nipped-B homolog (Drosophila)

Synonyms

Idn3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000059385

InnateDB Gene

IDBG-128592 (Nipbl)

Protein Structure

UniProt Annotation

Function

Probably plays a structural role in chromatin. Involved in sister chromatid cohesion, possibly by interacting with the cohesin complex (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005488	binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0036033	mediator complex binding
GO:0042826	histone deacetylase binding
GO:0047485	protein N-terminus binding
GO:0070087	chromo shadow domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0003007	heart morphogenesis
GO:0003151	outflow tract morphogenesis
GO:0006974	cellular response to DNA damage stimulus
GO:0007064	mitotic sister chromatid cohesion
GO:0007420	brain development
GO:0007507	heart development
GO:0007605	sensory perception of sound
GO:0019827	stem cell maintenance
GO:0031065	positive regulation of histone deacetylation
GO:0034088	maintenance of mitotic sister chromatid cohesion
GO:0034613	cellular protein localization
GO:0035115	embryonic forelimb morphogenesis
GO:0035136	forelimb morphogenesis
GO:0035261	external genitalia morphogenesis
GO:0040018	positive regulation of multicellular organism growth
GO:0042471	ear morphogenesis
GO:0042634	regulation of hair cycle
GO:0045444	fat cell differentiation
GO:0045778	positive regulation of ossification
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045995	regulation of embryonic development
GO:0048557	embryonic digestive tract morphogenesis
GO:0048589	developmental growth
GO:0048592	eye morphogenesis
GO:0048638	regulation of developmental growth
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0048703	embryonic viscerocranium morphogenesis
GO:0050890	cognition
GO:0060325	face morphogenesis
GO:0061010	gall bladder development
GO:0061038	uterus morphogenesis
GO:0071481	cellular response to X-ray