Version 5.4
Mus musculus Protein: Tbx10
Summary
InnateDB Protein IDBP-128666.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tbx10
Protein Name T-box 10
Synonyms Dc; Tbx13; Tbx7;
Species Mus musculus
Ensembl Protein ENSMUSP00000037401
InnateDB Gene IDBG-128664 (Tbx10)
Protein Structure
UniProt Annotation
Function Probable transcriptional regulator involved in developmental processes. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00201}.
Disease Associations Note=Defects in Tbx10 are the cause of a cleft lip and palate (CL/P) phenotype called Dancer (Dc). The defect is caused by a gain of function. {ECO:0000269PubMed:15118109}.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1261436
InterPro IPR001699 Transcription factor, T-box
IPR008967 p53-like transcription factor, DNA-binding
PFAM PF00907
PRINTS PR00937
PIRSF
SMART SM00425
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q810F8
PhosphoSite PhosphoSite-Q810F8
TrEMBL
UniProt Splice Variant
Entrez Gene 109575
UniGene Mm.246555
RefSeq NP_035663
MGI ID
MGI Symbol Tbx10
OMIM
CCDS CCDS29407
HPRD
IMGT
EMBL AF013283 AY229976 AY542280 BC109150 BC109151
GenPept AAC40116 AAI09151 AAI09152 AAO73482 AAS55456

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca