InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ndufv1

Summary

InnateDB Protein

IDBP-128755.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ndufv1

Protein Name

NADH dehydrogenase (ubiquinone) flavoprotein 1

Synonyms

CI-51kD;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000042967

InnateDB Gene

IDBG-128753 (Ndufv1)

Protein Structure

UniProt Annotation

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008137	NADH dehydrogenase (ubiquinone) activity
GO:0010181	FMN binding
GO:0016651	oxidoreductase activity, acting on NAD(P)H
GO:0046872	metal ion binding
GO:0051287	NAD binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0055114

oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005747	mitochondrial respiratory chain complex I

Protein Structure and Domains

PDB ID

MGI:107851

InterPro

IPR011537 NADH ubiquinone oxidoreductase, F subunit
IPR011538 NADH:ubiquinone oxidoreductase, 51kDa subunit
IPR019554 Soluble ligand binding domain
IPR019575 NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding

PFAM

PF01512
PF10531
PF10589

PRINTS

PIRSF

SMART

SM00928

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q91YT0