InnateDB Protein
|
IDBP-128772.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Slc1a3
|
Protein Name
|
solute carrier family 1 (glial high affinity glutamate transporter), member 3
|
Synonyms
|
AI504299; B430115D02Rik; Eaat1; GLAST; GLAST-1; GLU-T; GluT-1; Gmt1; MGluT1;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000005493
|
InnateDB Gene
|
IDBG-128770 (Slc1a3)
|
Protein Structure
|
|
Function |
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.
|
Subcellular Localization |
Membrane; Multi-pass membrane protein.
|
Disease Associations |
|
Tissue Specificity |
Localized in brain and is highly enriched in the Purkinje cell layer in cerebellum. Intermediate level in lung, low level in spleen, skeletal muscle and testis.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
3
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
4 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:99917
|
InterPro |
IPR001991
Sodium:dicarboxylate symporter
|
PFAM |
PF00375
|
PRINTS |
PR00173
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P56564
|
PhosphoSite |
PhosphoSite-P56564
|
TrEMBL |
Q543U3
|
UniProt Splice Variant |
|
Entrez Gene |
20512
|
UniGene |
Mm.473285
|
RefSeq |
NP_683740
|
MGI ID |
|
MGI Symbol |
Slc1a3
|
OMIM |
|
CCDS |
CCDS27373
|
HPRD |
|
IMGT |
|
EMBL |
AF330257
AK040798
AK045949
AK082736
AK158777
BC058711
BC066154
CH466581
|
GenPept |
AAH58711
AAH66154
AAK01708
BAC30705
BAC32544
BAC38592
BAE34658
EDL03327
|
|
|