Version 5.4
Mus musculus Protein: Ppp1r3a
Summary
InnateDB Protein IDBP-128778.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppp1r3a
Protein Name protein phosphatase 1, regulatory (inhibitor) subunit 3A
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000049054
InnateDB Gene IDBG-128776 (Ppp1r3a)
Protein Structure
UniProt Annotation
Function Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase. {ECO:0000269PubMed:11283248}.
Subcellular Localization Membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Skeletal muscle and heart. {ECO:0000269PubMed:11361130}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
Biological Process
GO:0005977 glycogen metabolic process
GO:0016311 dephosphorylation
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2153588
InterPro IPR005036 Putative phosphatase regulatory subunit
PFAM PF03370
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99MR9
PhosphoSite PhosphoSite-Q99MR9
TrEMBL
UniProt Splice Variant
Entrez Gene 140491
UniGene Mm.209429
RefSeq NP_536712
MGI ID
MGI Symbol Ppp1r3a
OMIM
CCDS CCDS19917
HPRD
IMGT
EMBL AF309628 AF309629 AK084518 AK084719 BC109007 CH466533
GenPept AAI09008 AAK31072 BAC39208 BAC39262 EDL13902

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca