Version 5.4
Mus musculus Protein: Akr1c21
Summary
InnateDB Protein IDBP-128784.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Akr1c21
Protein Name aldo-keto reductase family 1, member C21
Synonyms 9430025F20Rik; AI315367;
Species Mus musculus
Ensembl Protein ENSMUSP00000021628
InnateDB Gene IDBG-128782 (Akr1c21)
Protein Structure
UniProt Annotation
Function NADP-dependent 17-alpha-hydroxysteroid dehydrogenase that converts 5-alpha-androstane-3,17-dione into androsterone. Has lower 3-alpha-hydroxysteroid dehydrogenase activity. Has broad substrate specificity and acts on various 17-alpha- hydroxysteroids, 17-ketosteroids, 3-alpha hydroxysteroids and 3- ketosteroids. Reduction of keto groups is strictly stereoselective. Reduction of 17-ketosteroids yields only 17- alpha-hydroxysteroids. Likewise, reduction of 3-ketosteroids yields only 3-alpha-hydroxysteroids. {ECO:0000269PubMed:15577209, ECO:0000269PubMed:16018803, ECO:0000269PubMed:17034817, ECO:0000269PubMed:17442338, ECO:0000269PubMed:20124700}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Detected in kidney and brain. {ECO:0000269PubMed:15577209, ECO:0000269PubMed:16018803}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004033 aldo-keto reductase (NADP) activity
GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0047023 androsterone dehydrogenase activity
Biological Process
GO:0006694 steroid biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1924587
InterPro IPR020471 Aldo/keto reductase subgroup
IPR023210 NADP-dependent oxidoreductase domain
PFAM PF00248
PRINTS PR00069
PIRSF PIRSF000097
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91WR5
PhosphoSite PhosphoSite-Q91WR5
TrEMBL
UniProt Splice Variant
Entrez Gene 77337
UniGene
RefSeq NP_084177
MGI ID 3FJN
MGI Symbol Akr1c21
OMIM
CCDS CCDS26225
HPRD
IMGT
EMBL AB178898 AK020439 AY742217 BC013531 BC061057 BC091761
GenPept AAH13531 AAH61057 AAH91761 AAW65159 BAB32101 BAD18929

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca