Version 5.4
Mus musculus Protein: Tfec
Summary
InnateDB Protein IDBP-128915.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tfec
Protein Name transcription factor EC
Synonyms BB107417; bHLHe34; Tcfec;
Species Mus musculus
Ensembl Protein ENSMUSP00000031533
InnateDB Gene IDBG-128913 (Tfec)
Protein Structure
UniProt Annotation
Function Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter. Collaborates with MITF in target gene activation. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence) (By similarity). Binds to element F in an E-box sequence-specific manner (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form. {ECO:0000250, ECO:0000269PubMed:11818452}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00981}.
Disease Associations
Tissue Specificity Expressed in osteoclast-like cells (at protein level). Expressed in cells of the mononuclear phagocyte lineage. Expressed in macrophages and in osteoclast-like cells. {ECO:0000269PubMed:9973413}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0034605 cellular response to heat
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1333760
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR021802 Basic helix-loop-helix leucine zipper transcrition factor MiT/TFE
PFAM PF00010
PF11851
PRINTS
PIRSF
SMART SM00353
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WTW4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 21426
UniGene
RefSeq NP_112475
MGI ID
MGI Symbol Tfec
OMIM
CCDS CCDS19920
HPRD
IMGT
EMBL AF077742 AK137141 AK156327 AK159579 BC098494
GenPept AAD24426 AAH98494 BAE23248 BAE33676 BAE35199

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca