InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cav1

Summary

InnateDB Protein

IDBP-129002.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cav1

Protein Name

caveolin 1, caveolae protein

Synonyms

Cav; Cav-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000007799

InnateDB Gene

IDBG-129000 (Cav1)

Protein Structure

UniProt Annotation

Function

Involved in the costimulatory signal essential for T- cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G- protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. {ECO:0000269PubMed:10816572}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane, caveola {ECO:0000269PubMed:21610094}; Peripheral membrane protein {ECO:0000269PubMed:21610094}. Membrane raft {ECO:0000250}. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 114 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	38 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	114 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0016504	peptidase activator activity
GO:0019899	enzyme binding
GO:0050998	nitric-oxide synthase binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000165	MAPK cascade
GO:0000188	inactivation of MAPK activity
GO:0001525	angiogenesis
GO:0001570	vasculogenesis
GO:0001666	response to hypoxia
GO:0001937	negative regulation of endothelial cell proliferation
GO:0001960	negative regulation of cytokine-mediated signaling pathway
GO:0002026	regulation of the force of heart contraction
GO:0002931	response to ischemia
GO:0003057	regulation of the force of heart contraction by chemical signal
GO:0006641	triglyceride metabolic process
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006897	endocytosis
GO:0006940	regulation of smooth muscle contraction
GO:0007519	skeletal muscle tissue development
GO:0007595	lactation
GO:0008104	protein localization
GO:0008285	negative regulation of cell proliferation
GO:0009267	cellular response to starvation
GO:0009968	negative regulation of signal transduction
GO:0010524	positive regulation of calcium ion transport into cytosol
GO:0010952	positive regulation of peptidase activity
GO:0016050	vesicle organization
GO:0019217	regulation of fatty acid metabolic process
GO:0019915	lipid storage
GO:0030193	regulation of blood coagulation
GO:0030514	negative regulation of BMP signaling pathway
GO:0030857	negative regulation of epithelial cell differentiation
GO:0030879	mammary gland development
GO:0031295	T cell costimulation
GO:0031397	negative regulation of protein ubiquitination
GO:0032091	negative regulation of protein binding
GO:0032570	response to progesterone
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0033484	nitric oxide homeostasis
GO:0042310	vasoconstriction
GO:0042524	negative regulation of tyrosine phosphorylation of Stat5 protein
GO:0042632	cholesterol homeostasis
GO:0043407	negative regulation of MAP kinase activity
GO:0043409	negative regulation of MAPK cascade
GO:0043627	response to estrogen
GO:0045019	negative regulation of nitric oxide biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045907	positive regulation of vasoconstriction
GO:0046426	negative regulation of JAK-STAT cascade
GO:0048550	negative regulation of pinocytosis
GO:0048554	positive regulation of metalloenzyme activity
GO:0051001	negative regulation of nitric-oxide synthase activity
GO:0051259	protein oligomerization
GO:0051260	protein homooligomerization
GO:0051480	cytosolic calcium ion homeostasis
GO:0051592	response to calcium ion
GO:0051899	membrane depolarization
GO:0052547	regulation of peptidase activity
GO:0055074	calcium ion homeostasis
GO:0060056	mammary gland involution
GO:0070836	caveola assembly
GO:0071455	cellular response to hyperoxia
GO:0072584	caveolin-mediated endocytosis
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:0097190	apoptotic signaling pathway
GO:2000286	receptor internalization involved in canonical Wnt receptor signaling pathway
GO:2000811	negative regulation of anoikis
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0000139	Golgi membrane
GO:0002080	acrosomal membrane
GO:0005622	intracellular
GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005901	caveola
GO:0005929	cilium
GO:0005938	cell cortex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0031410	cytoplasmic vesicle
GO:0043234	protein complex
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm