Version 5.4
Mus musculus Protein: Cabp4
Summary
InnateDB Protein IDBP-129014.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cabp4
Protein Name calcium binding protein 4
Synonyms 2410038D05Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000025761
InnateDB Gene IDBG-129012 (Cabp4)
Protein Structure
UniProt Annotation
Function Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages. {ECO:0000269PubMed:15452577, ECO:0000269PubMed:16249514, ECO:0000269PubMed:17050707, ECO:0000269PubMed:17947313}.
Subcellular Localization Cytoplasm {ECO:0000250}. Note=Found in rod spherules and cone pedicles of the presynapses from both types of photoreceptors. {ECO:0000269PubMed:15452577}.
Disease Associations
Tissue Specificity Expressed in retina and in the inner hair cells (IHC) of the cochlea. {ECO:0000269PubMed:15452577, ECO:0000269PubMed:16249514, ECO:0000269PubMed:17050707, ECO:0000269PubMed:17947313}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0007601 visual perception
GO:0007602 phototransduction
GO:0008594 photoreceptor cell morphogenesis
GO:0046549 retinal cone cell development
GO:0060040 retinal bipolar neuron differentiation
Cellular Component
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:1920910
InterPro IPR002048 EF-hand domain
PFAM PF00036
PF13202
PF13405
PRINTS
PIRSF
SMART SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VHC5
PhosphoSite PhosphoSite-Q8VHC5
TrEMBL
UniProt Splice Variant
Entrez Gene 73660
UniGene
RefSeq NP_653115
MGI ID
MGI Symbol Cabp4
OMIM
CCDS CCDS29416
HPRD
IMGT
EMBL AY039218 BC049263
GenPept AAH49263 AAK83463

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca