InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Coro1b

Summary

InnateDB Protein

IDBP-129052.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Coro1b

Protein Name

coronin, actin binding protein 1B

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000008893

InnateDB Gene

IDBG-129050 (Coro1b)

Protein Structure

UniProt Annotation

Function

Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localized to the leading edge in fibroblasts, as well as weakly along actin stress fibers. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:16027158}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0051015	actin filament binding
GO:0071933	Arp2/3 complex binding

Biological Process

GO:0016477	cell migration
GO:0030036	actin cytoskeleton organization
GO:0031529	ruffle organization
GO:0034316	negative regulation of Arp2/3 complex-mediated actin nucleation
GO:0035767	endothelial cell chemotaxis
GO:0042060	wound healing
GO:0051017	actin filament bundle assembly
GO:0090135	actin filament branching
GO:1902463	protein localization to cell leading edge
GO:2000394	positive regulation of lamellipodium morphogenesis

Cellular Component

GO:0001725	stress fiber
GO:0005737	cytoplasm
GO:0005884	actin filament
GO:0015629	actin cytoskeleton
GO:0030027	lamellipodium
GO:0031252	cell leading edge
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1345963

InterPro

IPR001680 WD40 repeat
IPR015048 Domain of unknown function DUF1899
IPR015049 Domain of unknown function DUF1900
IPR017986 WD40-repeat-containing domain

PFAM

PF00400
PF08953
PF08954

PRINTS

PIRSF

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9WUM3