InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rps6kb2

Summary

InnateDB Protein

IDBP-129077.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rps6kb2

Protein Name

ribosomal protein S6 kinase, polypeptide 2

Synonyms

70kDa; S6K2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025749

InnateDB Gene

IDBG-129075 (Rps6kb2)

Protein Structure

UniProt Annotation

Function

Phosphorylates specifically ribosomal protein S6.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004711	ribosomal protein S6 kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042277	peptide binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0043491	protein kinase B signaling
GO:0045948	positive regulation of translational initiation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1927343

InterPro

IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR016238 Ribosomal protein S6 kinase
IPR017892 Protein kinase, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00433

PRINTS

PR00109

PIRSF

PIRSF000605

SMART

SM00133
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References