InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mefv

Summary

InnateDB Protein

IDBP-129149.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mefv

Protein Name

Mediterranean fever

Synonyms

FMF; pyrin; TRIM20;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023180

InnateDB Gene

IDBG-129147 (Mefv)

Protein Structure

UniProt Annotation

Function

Involved in innate immunity and the inflammatory response. Interacts with several components of the inflammasome complex, a large oligomeric structure which recruits and activates CASP1 and ultimately induces maturation of cytokines such as IL1B. However, the exact role of MEFV in the inflammatory pathway is uncertain as contradictory effects on IL1B processing have been reported in different experimental systems. Has been shown to activate IL1B production. Has also been shown to inhibit IL1B production. Also required for PSTPIP1-induced PYCARD oligomerization and for formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Can reduce PYCARD- induced apoptosis. Recruits PSTPIP1 to pyroptosomes, and required for PSTPIP1 oligomerization (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Nucleus {ECO:0000250}. Note=Associated with microtubules and with the filamentous actin of perinuclear filaments and peripheral lamellar ruffles. In pre-apoptotic cells, colocalizes with PYCARD/ASC in large specks (pyroptosomes). In migrating monocytes, strongly polarized at the leading edge of the cell where it colocalizes with polymerizing actin and PYCARD/ASC (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in spleen peripheral blood granulocytes. Not expressed in lymphocytes, thymus, testis, ovary, heart, brain, lung, liver, kidney and muscle. {ECO:0000269PubMed:10818206}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0008270	zinc ion binding

Biological Process

GO:0006954	inflammatory response
GO:0045087	innate immune response

Cellular Component

GO:0001726	ruffle
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005874	microtubule
GO:0005875	microtubule associated complex
GO:0030027	lamellipodium