InnateDB Protein
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IDBP-129197.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ppp1ca
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Protein Name
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protein phosphatase 1, catalytic subunit, alpha isoform
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Synonyms
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dism2; Ppp1c;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000039109
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InnateDB Gene
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IDBG-129195 (Ppp1ca)
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Protein Structure
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Function |
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. {ECO:0000269PubMed:17609112, ECO:0000269PubMed:21712997, ECO:0000269PubMed:21930935, ECO:0000269PubMed:22215812}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 271 interaction(s) predicted by orthology.
Experimentally validated |
Total |
58
[view]
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Protein-Protein |
58
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
271 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:103016
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InterPro |
IPR004843
Calcineurin-like phosphoesterase domain, apaH type
IPR006186
Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR029052
Metallo-dependent phosphatase-like
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PFAM |
PF00149
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PRINTS |
PR00114
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PIRSF |
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SMART |
SM00156
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TIGRFAMs |
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Modification |
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SwissProt |
P62137
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PhosphoSite |
PhosphoSite-P62137
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
19045
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UniGene |
Mm.474260
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RefSeq |
NP_114074
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MGI ID |
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MGI Symbol |
Ppp1ca
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OMIM |
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CCDS |
CCDS29421
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HPRD |
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IMGT |
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EMBL |
AK007932
AK028392
AK090070
AK151582
AK152667
AK153517
AK159575
AK167244
AK167538
AK167880
AK167981
BC014828
U25809
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GenPept |
AAC99814
AAH14828
BAB25358
BAC25928
BAC41078
BAE30522
BAE31402
BAE32060
BAE35196
BAE39365
BAE39605
BAE39893
BAE39973
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