Version 5.4
Mus musculus Protein: Plekhf2
Summary
InnateDB Protein IDBP-129212.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Plekhf2
Protein Name pleckstrin homology domain containing, family F (with FYVE domain) member 2
Synonyms 1110070J07Rik; AA673237; ZFYVE18;
Species Mus musculus
Ensembl Protein ENSMUSP00000054745
InnateDB Gene IDBG-129210 (Plekhf2)
Protein Structure
UniProt Annotation
Function May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport (By similarity). Enhances cellular sensitivity to TNF- induced apoptosis. {ECO:0000250, ECO:0000269PubMed:18288467}.
Subcellular Localization Early endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Note=Colocalizes with EEA1 and RAB5 at endosomal membrane fusion hot spots. May translocate to the endoplasmic reticulum in the early phase of apoptosis. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in brain, stomach and thymus, as well as in kidney, spleen, and skeletal muscle. Also expressed in peripheral blood mononuclear cells and dendritic cells. {ECO:0000269PubMed:18288467}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0015031 protein transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0030133 transport vesicle
GO:0031901 early endosome membrane
Protein Structure and Domains
PDB ID MGI:1919051
InterPro IPR000306 FYVE zinc finger
IPR001849 Pleckstrin homology domain
IPR011011 Zinc finger, FYVE/PHD-type
IPR017455 Zinc finger, FYVE-related
PFAM PF01363
PF00169
PRINTS
PIRSF
SMART SM00064
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91WB4
PhosphoSite PhosphoSite-Q91WB4
TrEMBL A8Y5N8
UniProt Splice Variant
Entrez Gene 71801
UniGene Mm.413417
RefSeq NP_780384
MGI ID
MGI Symbol Plekhf2
OMIM
CCDS CCDS17962
HPRD
IMGT
EMBL AK033666 AK154634 AL732497 BC016134 BC039276
GenPept AAH16134 AAH39276 BAC28417 BAE32730

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca