InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trp53inp1

Summary

InnateDB Protein

IDBP-129253.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trp53inp1

Protein Name

transformation related protein 53 inducible nuclear protein 1

Synonyms

2700057G22Rik; SIP; SIP18; SIP27; Stinp; Teap;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029865

InnateDB Gene

IDBG-129251 (Trp53inp1)

Protein Structure

UniProt Annotation

Function

Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC. {ECO:0000269PubMed:11557757, ECO:0000269PubMed:16044147, ECO:0000269PubMed:19118006, ECO:0000269PubMed:21339733}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000269PubMed:11557757}. Nucleus, PML body {ECO:0000250}. Cytoplasmic vesicle, autophagosome {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation. {ECO:0000250}.Isoform 2: Cytoplasm.

Disease Associations

Tissue Specificity

Ubiquitously expressed with highest levels in the thymus. {ECO:0000269PubMed:10630289, ECO:0000269PubMed:11557757}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016209	antioxidant activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006914	autophagy
GO:0006915	apoptotic process
GO:0007050	cell cycle arrest
GO:0008285	negative regulation of cell proliferation
GO:0009408	response to heat
GO:0010508	positive regulation of autophagy
GO:0030336	negative regulation of cell migration
GO:0034644	cellular response to UV
GO:0043065	positive regulation of apoptotic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048102	autophagic cell death
GO:0071361	cellular response to ethanol
GO:0071447	cellular response to hydroperoxide
GO:0072703	cellular response to methyl methanesulfonate
GO:2001235	positive regulation of apoptotic signaling pathway