Version 5.4
Mus musculus Protein: Impact
Summary
InnateDB Protein IDBP-129259.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Impact
Protein Name imprinted and ancient
Synonyms E430016J11Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000025290
InnateDB Gene IDBG-129257 (Impact)
Protein Structure
UniProt Annotation
Function Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its action on GCN2, may also facilitate neuritogenesis. {ECO:0000269PubMed:15937339, ECO:0000269PubMed:23447528}.
Subcellular Localization Cytoplasm {ECO:0000305PubMed:23447528}. Note=Association with polysomes is detectable in undifferentiated neuroblastoma cells, but it considerably increases after neuronal differentiation.
Disease Associations
Tissue Specificity Present in neurons in most areas of the brain. Present at high level in hypothalamus, particularly in the suprachiasmatic nucleus (at protein level). Preferentially expressed in brain, with a weaker expression in other tissues. {ECO:0000269PubMed:15937339, ECO:0000269PubMed:18260151, ECO:0000269PubMed:9256468}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001933 negative regulation of protein phosphorylation
GO:0006446 regulation of translational initiation
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1098233
InterPro IPR001498 Impact, N-terminal
IPR006575 RWD domain
IPR016135 Ubiquitin-conjugating enzyme/RWD-like
IPR020568 Ribosomal protein S5 domain 2-type fold
PFAM PF01205
PF05773
PRINTS
PIRSF
SMART SM00591
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O55091
PhosphoSite PhosphoSite-O55091
TrEMBL
UniProt Splice Variant
Entrez Gene 16210
UniGene Mm.490822
RefSeq NP_032404
MGI ID
MGI Symbol Impact
OMIM
CCDS CCDS29068
HPRD
IMGT
EMBL AF232228 AK138136 BC020524 D87973
GenPept AAG23916 AAH20524 BAA35139 BAE23558

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca