InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zfp521

Summary

InnateDB Protein

IDBP-129300.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zfp521

Protein Name

zinc finger protein 521

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025288

InnateDB Gene

IDBG-129298 (Zfp521)

Protein Structure

UniProt Annotation

Function

Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12393497}.

Disease Associations

Note=Defects in Znf521 are a cause of B-cell lymphomas. Znf521 gene is a frequent target of retroviral integration in murine B-cell lymphomas. Involved in most B-cell tumors in the AKXD-27 strain. Viral insertion causes overexpression resulting in the up-regulation of EBF1-target gene expression. Misexpression initiates tumorigenesis by perturbing B-cell development via an interaction with EBF1.

Tissue Specificity

Widely expressed. Expressed in all B-cell stages. {ECO:0000269PubMed:12393497}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0019904	protein domain specific binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0030154	cell differentiation