InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Psma8

Summary

InnateDB Protein

IDBP-129426.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Psma8

Protein Name

proteasome (prosome, macropain) subunit, alpha type, 8

Synonyms

2410072D24Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000042590

InnateDB Gene

IDBG-129424 (Psma8)

Protein Structure

UniProt Annotation

Function

Component of the spermatoproteasome, a form of the proteasome specifically found in testis that promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. {ECO:0000269PubMed:23706739}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004298	threonine-type endopeptidase activity

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0051603	proteolysis involved in cellular protein catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0005839	proteasome core complex
GO:0019773	proteasome core complex, alpha-subunit complex
GO:1990111	spermatoproteasome complex