InnateDB Protein
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IDBP-129434.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Tspan12
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Protein Name
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tetraspanin 12
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000031678
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InnateDB Gene
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IDBG-129430 (Tspan12)
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Protein Structure
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Function |
Regulator of cell surface receptor signal transduction. Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity (By similarity). Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta- catenin (CTNNB1). {ECO:0000250, ECO:0000269PubMed:19837033}.
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Subcellular Localization |
Cell membrane {ECO:0000305PubMed:19837033}; Multi-pass membrane protein {ECO:0000305PubMed:19837033}.
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Disease Associations |
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Tissue Specificity |
Expressed in the neonatal retinal vasculature but not other retinal tissues. Also detected in the neonatal meningeal vasculature and in nonvascular cell types, such as the smooth muscle cells in the neonatal intestine. {ECO:0000269PubMed:19837033}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1889818
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InterPro |
IPR000301
Tetraspanin
IPR008952
Tetraspanin, EC2 domain
IPR018499
Tetraspanin/Peripherin
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PFAM |
PF00335
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PRINTS |
PR00259
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PIRSF |
PIRSF002419
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BKT6
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PhosphoSite |
PhosphoSite-
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TrEMBL |
D3YYV7
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UniProt Splice Variant |
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Entrez Gene |
269831
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UniGene |
Mm.401178
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RefSeq |
NP_766595
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MGI ID |
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MGI Symbol |
Tspan12
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OMIM |
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CCDS |
CCDS19935
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HPRD |
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IMGT |
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EMBL |
AC122421
AC163104
AK033554
AK050737
BC065152
BC068240
CH466533
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GenPept |
AAH65152
AAH68240
BAC28354
BAC34399
EDL13857
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