Version 5.4
| Mus musculus Protein: Esrp1 | |||||||
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| Summary | |||||||
| InnateDB Protein | IDBP-129463.6 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | Esrp1 | ||||||
| Protein Name | epithelial splicing regulatory protein 1 | ||||||
| Synonyms | |||||||
| Species | Mus musculus | ||||||
| Ensembl Protein | ENSMUSP00000037921 | ||||||
| InnateDB Gene | IDBG-129461 (Esrp1) | ||||||
| Protein Structure |
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| UniProt Annotation | |||||||
| Function | mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity). {ECO:0000250}. | ||||||
| Subcellular Localization | Nucleus {ECO:0000250}. | ||||||
| Disease Associations | |||||||
| Tissue Specificity | Epithelial cell-specific. Epithelial-specific expression in diverse tissues and organs with particularly notable levels of expression in skin and gastrointestinal epithelia. {ECO:0000269PubMed:19285943}. | ||||||
| Comments | |||||||
| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||
| PDB ID | MGI:1917326 | ||||||
| InterPro |
IPR000504
RNA recognition motif domain IPR012337 Ribonuclease H-like domain |
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| PFAM |
PF00076
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| PRINTS | |||||||
| PIRSF | |||||||
| SMART |
SM00360
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| TIGRFAMs | |||||||
| Post-translational Modifications | |||||||
| Modification | |||||||
| Cross-References | |||||||
| SwissProt | |||||||
| PhosphoSite | PhosphoSite- | ||||||
| TrEMBL | Z4YJI3 | ||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 207920 | ||||||
| UniGene | Mm.387719 | ||||||
| RefSeq | XP_006537779 | ||||||
| MGI ID | |||||||
| MGI Symbol | Esrp1 | ||||||
| OMIM | |||||||
| CCDS | |||||||
| HPRD | |||||||
| IMGT | |||||||
| EMBL | AL772170 | ||||||
| GenPept | |||||||