InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FOS

Summary

InnateDB Protein

IDBP-12959.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FOS

Protein Name

FBJ murine osteosarcoma viral oncogene homolog

Synonyms

AP-1; C-FOS; p55;

Species

Homo sapiens

Ensembl Protein

ENSP00000306245

InnateDB Gene

IDBG-12957 (FOS)

Protein Structure

UniProt Annotation

Function

Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. {ECO:0000269PubMed:16055710, ECO:0000269PubMed:17160021, ECO:0000269PubMed:22105363, ECO:0000269PubMed:7588633, ECO:0000269PubMed:9732876}.

Subcellular Localization

Nucleus. Endoplasmic reticulum. Cytoplasm, cytosol. Note=In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 186 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Experimentally validated
Total	186 [view]
Protein-Protein	134 [view]
Protein-DNA	49 [view]
Protein-RNA	1 [view]
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0070412	R-SMAD binding

Biological Process

GO:0001661	conditioned taste aversion
GO:0002224	toll-like receptor signaling pathway
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006306	DNA methylation
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006954	inflammatory response
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007399	nervous system development
GO:0007565	female pregnancy
GO:0007568	aging
GO:0009409	response to cold
GO:0009416	response to light stimulus
GO:0009612	response to mechanical stimulus
GO:0009629	response to gravity
GO:0009636	response to toxic substance
GO:0014070	response to organic cyclic compound
GO:0030431	sleep
GO:0031668	cellular response to extracellular stimulus
GO:0032496	response to lipopolysaccharide
GO:0032570	response to progesterone
GO:0032870	cellular response to hormone stimulus
GO:0034097	response to cytokine
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0034166	toll-like receptor 10 signaling pathway
GO:0034614	cellular response to reactive oxygen species
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0035902	response to immobilization stress
GO:0035914	skeletal muscle cell differentiation
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0042493	response to drug
GO:0045087	innate immune response
GO:0045672	positive regulation of osteoclast differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity
GO:0051403	stress-activated MAPK cascade
GO:0051412	response to corticosterone
GO:0051591	response to cAMP
GO:0060395	SMAD protein signal transduction
GO:0071277	cellular response to calcium ion

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0016020	membrane
GO:0043005	neuron projection