Version 5.4
Mus musculus Protein: Syt12
Summary
InnateDB Protein IDBP-129617.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Syt12
Protein Name synaptotagmin XII
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000055237
InnateDB Gene IDBG-129615 (Syt12)
Protein Structure
UniProt Annotation
Function May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. {ECO:0000250}.
Subcellular Localization Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
Biological Process
GO:0006810 transport
Cellular Component
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030672 synaptic vesicle membrane
Protein Structure and Domains
PDB ID MGI:2159601
InterPro IPR000008 C2 domain
IPR001565 Synaptotagmin
PFAM PF00168
PRINTS PR00360
PR00399
PIRSF
SMART SM00239
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q920N7
PhosphoSite PhosphoSite-Q920N7
TrEMBL Q14AG7
UniProt Splice Variant
Entrez Gene 171180
UniGene Mm.262270
RefSeq NP_598925
MGI ID
MGI Symbol Syt12
OMIM
CCDS CCDS29428
HPRD
IMGT
EMBL AB062804 AK046627 AK083139 BC116846 BC116848 CH466612
GenPept AAI16847 AAI16849 BAB69674 BAC32812 BAC38779 EDL33051

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca