InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dsc2

Summary

InnateDB Protein

IDBP-129631.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dsc2

Protein Name

desmocollin 2

Synonyms

AW228162; Dsc2a; Dsc2b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000042905

InnateDB Gene

IDBG-129629 (Dsc2)

Protein Structure

UniProt Annotation

Function

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.

Disease Associations

Tissue Specificity

In all epithelia tested and heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0007156	homophilic cell adhesion
GO:0009267	cellular response to starvation
GO:0086005	ventricular cardiac muscle cell action potential
GO:0086042	cardiac muscle cell-cardiac muscle cell adhesion
GO:0086069	bundle of His cell to Purkinje myocyte communication
GO:0086091	regulation of heart rate by cardiac conduction

Cellular Component

GO:0005886	plasma membrane
GO:0005913	cell-cell adherens junction
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030057	desmosome
GO:0031410	cytoplasmic vesicle
GO:0070062	extracellular vesicular exosome